curvature
Ligands that decrease DNA curvature
Ligand: Lexitropsin
Effect on DNA structure: Reduces curvature
Reference(s):
Randrianarivelo, M., Zakrzewsky, K. and Pullman, B. Theoretical Modeling of Monocationic- Lexitropsin Complexation: Influence of Ligand Binding on DNA Curvature
Journal of Biomolecular Structure and Dynamics 6 (4): 769-779 (1989).
Reinart, K.E., Stutter, E., Zimmer, C. and Lown, J.W. DNA Interaction of the Imidazole-containing Lexitropsin ImPy: Titration Viscometric Study in Comparison to Netropsin
J. Biomolecular Structure and Dynamics 12 (4): 847-855 (1995)
Ligand: Daunomycin
Effect on DNA structure: Reduces curvature
Reference(s): Bailly, C., Minnock, A. and Waring, M.J.
A Simple Ligation Assay to Detect Effects of Drugs on the Curvature/Flexibility of DNA
FEBS Letters 396:253-256 (1996)
Ligand: Mitoxantrone
Effect on DNA structure: Reduces curvature
Reference(s):Bailly, C., Minnock, A. and Waring, M.J.
A Simple Ligation Assay to Detect Effects of Drugs on the Curvature/Flexibility of DNA
FEBS Letters 396:253-256 (1996)
Ligands that increase DNA curvature
Ligand: Amsacrine
Effect on DNA structure: Increases curvature
Reference(s): Bailly, C., Minnock, A. and Waring, M.J.
A Simple Ligation Assay to Detect Effects of Drugs on the Curvature/Flexibility of DNA
FEBS Letters 396:253-256 (1996)
Ligand: A series of 13 compounds, mostly benzimidazole derivatives
Effect on DNA structure: Increases curvature
Reference(s): Hunt, R.A., Munde, M., Kumar, A., Ismail, M.A., Farahat, A.A., Arafa, R.K., Say, M., Batista-Parra, A., Tevis, D., Boykin, D.W. and Wilson, W.D. Induced Topological Changes in DNA Complexes: Influence of DNA Sequences and Small Molecule Structures
Nucleic Acids Research 39(10):4265-4274 (2011)
http://nar.oxfordjournals.org/content/39/10/4265.full