The Leifer Institute for Molecular and Digital Pathology

The Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital Pathology

(732) 415-8371

  • Home
  • History and Background
  • Projects Overview
  • Ligands
  • LigandsList
    • Outline
    • Tertiary Structure
    • Curvature
    • Supercoiling
    • LInear Length
    • Secondary Structure
    • Z-DNA
    • G-quadruplexes
    • i-motifs
    • Cruciform DNA
    • Triple Stranded DNA
    • Ligands and Mechanism
    • Binding to Bases
    • Intercalation
    • Enantiomers
    • Natural ligands
    • Metals
    • Antitumor Drugs
  • Pressure
  • MCS
    • Introduction
    • Research
    • Articles
    • Videos
    • Resources
  • Regulogenesis
  • 3D
  • Virtual Lab
  • Data Mining
  • Wiki Use
  • Foldscope
  • Gallery
  • Personal
    • Publications
  • Slide 10
  • More
    • Home
    • History and Background
    • Projects Overview
    • Ligands
    • LigandsList
      • Outline
      • Tertiary Structure
      • Curvature
      • Supercoiling
      • LInear Length
      • Secondary Structure
      • Z-DNA
      • G-quadruplexes
      • i-motifs
      • Cruciform DNA
      • Triple Stranded DNA
      • Ligands and Mechanism
      • Binding to Bases
      • Intercalation
      • Enantiomers
      • Natural ligands
      • Metals
      • Antitumor Drugs
    • Pressure
    • MCS
      • Introduction
      • Research
      • Articles
      • Videos
      • Resources
    • Regulogenesis
    • 3D
    • Virtual Lab
    • Data Mining
    • Wiki Use
    • Foldscope
    • Gallery
    • Personal
      • Publications
    • Slide 10

The Leifer Institute for Molecular and Digital Pathology

The Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital Pathology

(732) 415-8371

  • Home
  • History and Background
  • Projects Overview
  • Ligands
  • LigandsList
    • Outline
    • Tertiary Structure
    • Curvature
    • Supercoiling
    • LInear Length
    • Secondary Structure
    • Z-DNA
    • G-quadruplexes
    • i-motifs
    • Cruciform DNA
    • Triple Stranded DNA
    • Ligands and Mechanism
    • Binding to Bases
    • Intercalation
    • Enantiomers
    • Natural ligands
    • Metals
    • Antitumor Drugs
  • Pressure
  • MCS
    • Introduction
    • Research
    • Articles
    • Videos
    • Resources
  • Regulogenesis
  • 3D
  • Virtual Lab
  • Data Mining
  • Wiki Use
  • Foldscope
  • Gallery
  • Personal
    • Publications
  • Slide 10

curvature

 

Ligands that decrease DNA curvature

Ligand: Lexitropsin

Effect on DNA structure: Reduces curvature

Reference(s):
Randrianarivelo, M., Zakrzewsky, K. and Pullman, B. Theoretical Modeling of Monocationic- Lexitropsin Complexation: Influence of Ligand Binding on DNA Curvature
Journal of Biomolecular Structure and Dynamics 6 (4): 769-779 (1989).

Reinart, K.E., Stutter, E., Zimmer, C. and Lown, J.W. DNA Interaction of the Imidazole-containing Lexitropsin ImPy: Titration Viscometric Study in Comparison to Netropsin
J. Biomolecular Structure and Dynamics 12 (4): 847-855 (1995)

Ligand: Daunomycin

Effect on DNA structure: Reduces curvature

Reference(s): Bailly, C., Minnock, A. and Waring, M.J.
A Simple Ligation Assay to Detect Effects of Drugs on the Curvature/Flexibility of DNA
FEBS Letters 396:253-256 (1996)

Ligand: Mitoxantrone

Effect on DNA structure: Reduces curvature

Reference(s):Bailly, C., Minnock, A. and Waring, M.J.
A Simple Ligation Assay to Detect Effects of Drugs on the Curvature/Flexibility of DNA
FEBS Letters 396:253-256 (1996)
 


 

Ligands that increase DNA curvatureThis is a featured page

Ligand: Amsacrine

Effect on DNA structure: Increases curvature

Reference(s): Bailly, C., Minnock, A. and Waring, M.J.
A Simple Ligation Assay to Detect Effects of Drugs on the Curvature/Flexibility of DNA
FEBS Letters 396:253-256 (1996)

Ligand: A series of 13 compounds, mostly benzimidazole derivatives

Effect on DNA structure: Increases curvature

Reference(s): Hunt, R.A., Munde, M., Kumar, A., Ismail, M.A., Farahat, A.A., Arafa, R.K., Say, M., Batista-Parra, A., Tevis, D., Boykin, D.W. and Wilson, W.D. Induced Topological Changes in DNA Complexes: Influence of DNA Sequences and Small Molecule Structures
Nucleic Acids Research 39(10):4265-4274 (2011)
http://nar.oxfordjournals.org/content/39/10/4265.full


Leifer Inst for Molecular and Digital Pathology

(732) 415-8371

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