The Leifer Institute for Molecular and Digital Pathology

The Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital Pathology

(732) 415-8371

  • Home
  • History and Background
  • Projects Overview
  • Ligands
  • LigandsList
    • Outline
    • Secondary Structure
    • Z-DNA
    • G-quadruplexes
    • i-motifs
    • Cruciform DNA
    • Triple Stranded DNA
    • Tertiary Structure
    • Curvature
    • Twisting
    • Stretching
    • Supercoiling
    • Ligands and Mechanism
    • Binding to Bases
    • Intercalation
    • Enantiomers
    • Natural ligands
    • Metals
    • Antitumor Drugs
  • Pressure
  • MCS
    • Introduction
    • Research
    • Articles
    • Videos
    • Resources
  • Regulogenesis
  • 3D
  • Virtual Lab
  • Data Mining
  • Wiki Use
  • Foldscope
  • Gallery
  • Personal
    • Publications
  • Slide 10
  • More
    • Home
    • History and Background
    • Projects Overview
    • Ligands
    • LigandsList
      • Outline
      • Secondary Structure
      • Z-DNA
      • G-quadruplexes
      • i-motifs
      • Cruciform DNA
      • Triple Stranded DNA
      • Tertiary Structure
      • Curvature
      • Twisting
      • Stretching
      • Supercoiling
      • Ligands and Mechanism
      • Binding to Bases
      • Intercalation
      • Enantiomers
      • Natural ligands
      • Metals
      • Antitumor Drugs
    • Pressure
    • MCS
      • Introduction
      • Research
      • Articles
      • Videos
      • Resources
    • Regulogenesis
    • 3D
    • Virtual Lab
    • Data Mining
    • Wiki Use
    • Foldscope
    • Gallery
    • Personal
      • Publications
    • Slide 10

The Leifer Institute for Molecular and Digital Pathology

The Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital Pathology

(732) 415-8371

  • Home
  • History and Background
  • Projects Overview
  • Ligands
  • LigandsList
    • Outline
    • Secondary Structure
    • Z-DNA
    • G-quadruplexes
    • i-motifs
    • Cruciform DNA
    • Triple Stranded DNA
    • Tertiary Structure
    • Curvature
    • Twisting
    • Stretching
    • Supercoiling
    • Ligands and Mechanism
    • Binding to Bases
    • Intercalation
    • Enantiomers
    • Natural ligands
    • Metals
    • Antitumor Drugs
  • Pressure
  • MCS
    • Introduction
    • Research
    • Articles
    • Videos
    • Resources
  • Regulogenesis
  • 3D
  • Virtual Lab
  • Data Mining
  • Wiki Use
  • Foldscope
  • Gallery
  • Personal
    • Publications
  • Slide 10

Secondary structure

In addition to its primary structure, DNA can be described in terms of its secondary structure.

The Secondary structure of DNA describes the parameters of the double stranded macromolecule as a whole.  See Image Gallery  (Images 1-4)



For B-DNA (Classic or Watson-Crick DNA) Secondary Structure  includes such features as:


                                 Strands: 

                                                   Two strands

                                                    Plectonemically coiled (twisted around each other, in helical form)

                                                    Antiparallel (one 5' to 3'; the other 3' to 5')

                                                    

                                 

                                 Backbone:  

                                                    Smooth backbone line

                                                    No irregular features

                                                    Backbone on the outside, base-pairs on the inside                               

                                                   

                                Bases:                                            

                                                    Bases paired        (A-T,  G-C)

                                                    Base-pairs flat, planar                         

                                                    10 bases per turn

                                

                                The  Double Helix:                       

                                                   Right-handed helix (clockwise)

                                                   Symmetrical


Z-DNA

For ligands, go to Z-DNA page


  

left-handed helix (counterclockwise)

backbone zigs and zags

12 bases per turn

bases turned and flipped




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Leifer Inst for Molecular and Digital Pathology

(732) 415-8371

Copyright © 2018 Leifer Institute for Molecular and Digital Pathology - All Rights Reserved.

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