The Leifer Institute for Molecular and Digital Pathology

The Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital Pathology

(732) 415-8371

  • Home
  • History and Background
  • Projects Overview
  • Ligands
  • LigandsList
    • Outline
    • Secondary Structure
    • Z-DNA
    • G-quadruplexes
    • i-motifs
    • Cruciform DNA
    • Triple Stranded DNA
    • Tertiary Structure
    • Curvature
    • Twisting
    • Stretching
    • Supercoiling
    • Ligands and Mechanism
    • Binding to Bases
    • Intercalation
    • Enantiomers
    • Natural ligands
    • Metals
    • Antitumor Drugs
  • Pressure
  • MCS
    • Introduction
    • Research
    • Articles
    • Videos
    • Resources
  • Regulogenesis
  • 3D
  • Virtual Lab
  • Data Mining
  • Wiki Use
  • Foldscope
  • Gallery
  • Personal
    • Publications
  • Slide 10
  • More
    • Home
    • History and Background
    • Projects Overview
    • Ligands
    • LigandsList
      • Outline
      • Secondary Structure
      • Z-DNA
      • G-quadruplexes
      • i-motifs
      • Cruciform DNA
      • Triple Stranded DNA
      • Tertiary Structure
      • Curvature
      • Twisting
      • Stretching
      • Supercoiling
      • Ligands and Mechanism
      • Binding to Bases
      • Intercalation
      • Enantiomers
      • Natural ligands
      • Metals
      • Antitumor Drugs
    • Pressure
    • MCS
      • Introduction
      • Research
      • Articles
      • Videos
      • Resources
    • Regulogenesis
    • 3D
    • Virtual Lab
    • Data Mining
    • Wiki Use
    • Foldscope
    • Gallery
    • Personal
      • Publications
    • Slide 10

The Leifer Institute for Molecular and Digital Pathology

The Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital Pathology

(732) 415-8371

  • Home
  • History and Background
  • Projects Overview
  • Ligands
  • LigandsList
    • Outline
    • Secondary Structure
    • Z-DNA
    • G-quadruplexes
    • i-motifs
    • Cruciform DNA
    • Triple Stranded DNA
    • Tertiary Structure
    • Curvature
    • Twisting
    • Stretching
    • Supercoiling
    • Ligands and Mechanism
    • Binding to Bases
    • Intercalation
    • Enantiomers
    • Natural ligands
    • Metals
    • Antitumor Drugs
  • Pressure
  • MCS
    • Introduction
    • Research
    • Articles
    • Videos
    • Resources
  • Regulogenesis
  • 3D
  • Virtual Lab
  • Data Mining
  • Wiki Use
  • Foldscope
  • Gallery
  • Personal
    • Publications
  • Slide 10

Ligands and Gene Regulation

This section reflects a long-standing interest of mine in gene regulation. I started my career looking  into the role of polyamines in bacterial and (by extensive literature) in human biology, especially as it related to cancer. The second phase  of my work was involved in the development of bacterial test systems to determine which environmental chemicals were mutagenic or DNA-damaging, in the conceptual framework (and experimentally shown) that these would be potential carcinogens. This in turn led me to consider that there might be chemicals that do not change the primary sequence of the DNA or its structural integrity but rather act to modify the secondary or tertiary structure of the DNA in such a way as to affect the binding of regulatory proteins. Depending on the gene, and, I suspect, the timing of the sometimes transient chemical interaction, could result on effects not only on carcinogenesis but also on development, aging and particular pathologies.


Click on LigandsList Outline Tab



  

51. Leifer, Z. (2016). “The Effect of Small Molecule Ligands on DNA Structure: A 

Dictionary and a Wiki”. Poster Presented at the Cell Symposium: Transcription 

Regulation in Development and Disease. June 26-28, 2016, Chicago, IL. Published in 

Poster listings at the Symposium.  


  

55. Leifer, Z. (2018). E-Poster: “The Role of G-Quadruplex Structures in DNA, Ligands That Affect Them and Their Effect on Human Health and Disease: A Review of Recent Literature and A Proposal” at the LabRoots Online Conference on Genetics and Genomics  (May 9-10, 2018).

https://www.eposters.net/poster/the-role-of-g-quadruplex-structures-in-dna-ligands-that-affect-them-and-their-effect-on-human


  

Singh, V. and Leifer, Z. (2018). G-Quadruplex Structures in Microbial DNA - A Role in Basic Biology and a Possible Antimicrobial Target: A Review of Recent Literature and a Proposal. Presented in e-poster format at the Labroots Online Conference on Microbiology and Immunology 

https://events.labroots.com/event/MicrobiologyandImmunology2018/en-us#!/PosterHall/n280328


https://www.eposters.net/poster/g-quadruplex-structures-in-microbial-dna-a-role-in-basic-biology-and-a-possible-antimicrobial


https://www.researchgate.net/profile/Zev_Leifer/research

 Small Molecules and DNA Structure 📷


This site provides an organized and annotated compilation ("a dictionary") of the effect of various small molecule ligands on DNA structure at multiple levels. Where known, the effect on structure as it relates to protein binding is indicated.  This site is owned, edited and curated by:  Zev Leifer, Ph.D., President and Chief  Research Officer of The Leifer Institute for Molecular and Digital Pathology and Professor of Microbiology and Pathology Emeritus,  New York College of Podiatric Medicine New York, NY  All colleagues interested in participating in this project, contact Dr. Leifer at zleifer@limdp.org

 




outline

  



http://ligandsanddna.wordpress.com



Ligands that affect structure



Secondary Structure

Z-DNA
G-quadruplexes
   G-quadruplex-binding ligands
i-motifs
   i-motif binding ligands
cruciform DNA
   cruciform DNA-binding ligands
Triple stranded DNA
    Triplex-binding ligands


Tertiary Structure

Curvature
   Ligands that decrease DNA curvature
   Ligands that increase DNA curvature
Twisting
Stretching
   Length -modifying ligands

Supercoiling

Ligands and mechanism

    Binding to bases
   Intercalation
   Stereochemical enantiomers

Naturally-occurring DNA-binding ligands

The role of metals

Antitumor Drugs that target DNA Structure


My Blog

Leifer Inst for Molecular and Digital Pathology

(732) 415-8371

Copyright © 2018 Leifer Institute for Molecular and Digital Pathology - All Rights Reserved.

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