outline
Ligands that affect structure
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Curvature
Ligands that decrease DNA curvature
Ligands that increase DNA curvature
Supercoiling
Linear Length
Length -modifying ligands
Secondary Structure
Z-DNA
G-quadruplexes
G-quadruplex-binding ligands
i-motifs
i-motif binding ligands
Cruciform DNA
cruciform DNA-binding ligands
Triple stranded DNA
Triplex-binding ligands
Ligands and mechanism
Binding to bases
Intercalation
Stereochemical enantiomers
Naturally-occurring DNA-binding ligands
The role of metals
Antitumor Drugs that target DNA Structure