outline

Ligands that affect structure

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Secondary Structure

G-quadruplex-binding ligands

i-motif binding ligands

cruciform DNA-binding ligands

Triple stranded DNA

Triplex-binding ligands

Tertiary Structure

Ligands that decrease DNA curvature

Ligands that increase DNA curvature

Length -modifying ligands

Ligands and mechanism

Binding to bases

Stereochemical enantiomers

Naturally-occurring DNA-binding ligands

The role of metals

Antitumor Drugs that target DNA Structure