The Leifer Institute for Molecular and Digital Pathology

The Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital Pathology

(929) 269-7268

  • Home
  • History and Background
  • Projects Overview
  • Ligands
  • LigandsList
    • Outline
    • Tertiary Structure
    • Curvature
    • Supercoiling
    • LInear Length
    • Secondary Structure
    • Z-DNA
    • G-quadruplexes
    • i-motifs
    • Cruciform DNA
    • Triple Stranded DNA
    • Ligands and Mechanism
    • Binding to Bases
    • Intercalation
    • Enantiomers
    • Natural ligands
    • Metals
    • Antitumor Drugs
  • Pressure
  • Regulogenesis
  • 3D
  • Virtual Lab
  • Data Mining
  • Wiki Use
  • Gallery
  • More
    • Home
    • History and Background
    • Projects Overview
    • Ligands
    • LigandsList
      • Outline
      • Tertiary Structure
      • Curvature
      • Supercoiling
      • LInear Length
      • Secondary Structure
      • Z-DNA
      • G-quadruplexes
      • i-motifs
      • Cruciform DNA
      • Triple Stranded DNA
      • Ligands and Mechanism
      • Binding to Bases
      • Intercalation
      • Enantiomers
      • Natural ligands
      • Metals
      • Antitumor Drugs
    • Pressure
    • Regulogenesis
    • 3D
    • Virtual Lab
    • Data Mining
    • Wiki Use
    • Gallery

The Leifer Institute for Molecular and Digital Pathology

The Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital PathologyThe Leifer Institute for Molecular and Digital Pathology

(929) 269-7268

  • Home
  • History and Background
  • Projects Overview
  • Ligands
  • LigandsList
  • Pressure
  • Regulogenesis
  • 3D
  • Virtual Lab
  • Data Mining
  • Wiki Use
  • Gallery

natural ligands

  

Naturally-occurring DNA-binding ligands

Ligand: Spermidine  Effect on DNA structure: Affects bending    


Reference(s): Feuerstein, B.G., Pattabiraman and Marton, L.J. Molecular Mechanics of the Interactions of Spermine with DNA: DNA bending as a result of ligand binding. Nucleic Acids Res. 18(5):1271-1282 (1990) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC330444/   


Ligand: Spermidine and Spermine  


Effect on DNA structure: Increase writhing and limit twisting  


Reference(s): Shao, Q., Goyal S., Finzi, L. and Dunlap, D. Physiological Levels of Salt and Polyamines favor writhe and limit twist in DNA. Macromolecules 45(7):3188-3196 (2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601208/
 

Leifer Inst for Molecular and Digital Pathology

(929) 269-7268

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