Ligand: Spermidine
Effect on DNA structure: Affects bending
Reference(s): Feuerstein, B.G., Pattabiraman and Marton, L.J. Molecular Mechanics of the Interactions of Spermine with DNA: DNA bending as a result of ligand binding. Nucleic Acids Res. 18(5):1271-1282 (1990) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC330444/
Ligand: Spermidine and Spermine
Effect on DNA structure: Increase writhing and limit twisting
Reference(s): Shao, Q., Goyal S., Finzi, L. and Dunlap, D. Physiological Levels of Salt and Polyamines favor writhe and limit twist in DNA. Macromolecules 45(7):3188-3196 (2012) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601208/
Ligand: Spermine (vs. others)
Effect on DNA structure: Decrease binding of antinuclear antibodies
Reference: Wang, X., Stearns, N.A., Xingfu, L. and Pisetsky, D.S. The Effect of Polyamines on the Binding of Anti-DNA Antibodies for Patients with SLE and Normal Human Subjects. Clinical Immunology 153(1):94-103 (2014)
https://www.sciencedirect.com/science/article/abs/pii/S1521661614000886?via%3Dihub
Leifer Inst for Molecular and Digital Pathology
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